NAPLEX Practice Questions

NAPLEX practice questions can help you in your study plan and exam preparation. The right NAPLEX exam pre material matters more than you think if you are just starting the naplex exam preparation or doing last-minute review.

In this article, we will help you prepare for your big day with practice questions and other related resources: Here is what this article contains

  • Realistic NAPLEX sample questions to test your knowledge

  • Trusted sources for the best NAPLEX prep questions

  • Pro tips to make your practice tests feel like the real exam

We’ll show you how to spot your weak areas and turn them into strengths. Because passing the NAPLEX isn’t about luck—it’s about smart prep.

Ready to study like a pro? Let’s dive in.

Why Are NAPLEX Exam Practice Questions Important?

The North American Pharmacist Licensure Examination (NAPLEX) tests your ability to apply knowledge in real-world pharmacy settings. Using NAPLEX exam questions that simulate the actual exam format helps:

  • Familiarize yourself with question types and difficulty
  • Build test-taking confidence
  • Identify weak areas for targeted revision
  • Reduce exam-day anxiety

Free Sample NAPLEX Practice Questions

Targiniq ER is an extended-release/long-acting (ER/LA) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Which of the following drugs provides abuse-deterrent property to Targiniq ER?

A. Oxycodone
B. Naltrexone
C. Naloxone
D. Methadone

Answer: C. Naloxone

Explanation:
The active ingredients found in Targiniq ER are Oxycodone and Naloxone. It is an extended-release/long-acting (ER/LA) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
 
Targiniq ER has properties that are expected to deter, but not totally prevent, abuse of the drug by snorting and injection. When crushed and snorted, or crushed, dissolved and injected, the naloxone in Targiniq ER blocks the euphoric effects of oxycodone, making it less liked by abusers than oxycodone alone. Naloxone is a medication that is commonly used to reverse the effects of opioid overdose. Targiniq ER can still be abused, including when taken orally (by mouth), which is currently the most common way oxycodone is abused.
 
Constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, abdominal pain, anxiety, and sweating are commonly reported side effects of (Oxycodone + Naloxone) Targiniq ER.

A. Vazculep
B. Sivextro
C. Bunavail
D. Afrezza

Answer: D. Afrezza

Explanation:
he U.S. Food and Drug Administration has approved Afrezza (insulin human) Inhalation Powder, a rapid-acting inhaled insulin to improve glycemic control in adults with diabetes mellitus. Afrezza is available as single-use cartridges of (4 units, 8 units and 12 units).  
 
Afrezza is a rapid-acting inhaled insulin that is administered at the beginning of each meal.Afrezza should only be administered via oral inhalation using  the AFREZZA Inhaler. Afrezza is administered using a single inhalation per cartridge.
 
Afrezza is not a substitute for long-acting insulin. Afrezza must be used in combination with long-acting insulin in patients with type 1 diabetes, and it is not recommended for the treatment of diabetic ketoacidosis, or in patients who smoke.
 
Step 1: Starting Mealtime Dose:

1. Insulin Naïve Individuals: Start on 4 units of Afrezza at each meal.

2.  Individuals Using Subcutaneous Mealtime (Prandial) Insulin:  Determine the appropriate Afrezza dose for each meal by  converting from the injected dose using Figure 1.

3. Individuals Using Subcutaneous Pre-mixed Insulin: Estimate  the mealtime injected dose by dividing half of the total daily injected pre-mixed insulin dose equally among the three meals of the day. Convert each estimated injected mealtime dose to an appropriate Afrezza dose using Figure 1. Administer half of the total daily injected pre-mixed dose as an injected basal  insulin dose.

I. It is indicated for treating a suspected opioid overdose.
 
II. The principal advantage of Naloxone is that it doesn’t cause withdrawal symptoms such as sweating, increased heart rate or agitation even in an opioid dependent patient.
 
III. A person should use great caution to administer Naloxone to someone who is not using opioids.
 
a. I only
b. I and II only
c. All
d. None of the above

Answer: (a) I is True only. 

Explanation:
 Naloxone HCL (Evzio) is a pre-filled, single-use auto-injector. Naloxone HCL (Evzio) is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression.
 
Naloxone HCL (Evzio) is intended for immediate administration as emergency therapy in settings where opioids may be present. It is for intramuscular and subcutaneous use only. Administer the initial dose of Naloxone HCL (Evzio) to adult or pediatric patients intramuscularly or subcutaneously into the anterolateral aspect of the thigh, through clothing if necessary. There’s no harm in giving Naloxone HCL (Evzio) to someone who is not using opioids.
 
Naloxone HCL (Evzio) can trigger withdrawal symptoms such as sweating, increased heart rate, or agitation in the opioid dependent patient. Hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnea, pulmonary edema, and cardiac arrest are commonly reported side effects of Naloxone HCl (Evzio).

a. Schedule III controlled drug
b. Schedule IV controlled drug
c. Schedule V controlled drug
d. Non-controlled substance

Answer (a): Schedule III controlled drug

Explanation:
To be exempt from controlled substance requirement, the ratio of Acetaminophen to Butalbital is set to 70:15. In other words, for every 15mg Butalbital, there shall be at least 70 mg or more Acetaminophen required to exempt the formulation from controlled substance requirement.

In above prescription, the quantity of Butalbital is 50 mg; to exempt it from controlled substance requirement, we need to mix it with at least 233 mg or more Acetaminophen. The prescriber has requested Acetaminophen quantity to be set to 200mg; therefore the final formulation shall be classified as Schedule III controlled substance.

I. Methamphetamine is a highly addictive drug that can be manufactured in small and portable laboratories.

II. The use of methamphetamine can result in fatal kidney and lung disorders, brain damage, liver damage and blood clots.

III. Each pound of methamphetamine produced leaves behind five to six pounds of toxic waste.

IV. Children born to mothers who are abusers of methamphetamine can be born addicted and suffer birth defects, low birth weight, tremors, excessive crying, attention deficit disorder and behavior disorders.
 
a. I only
b. I and IV only
c. II only
d. All

Answer: (d) All.

Explanation:
The illegal production and distribution of methamphetamine is an increasing problem nationwide. The methamphetamine is a highly addictive drug that can be manufactured in small and portable laboratories. These laboratories are operated by individuals who manufacture the drug in a clandestine and unsafe manner, often resulting in explosions and fires that can injure not only the individuals involved, but their families, neighbors, law-enforcement officers and firemen.
 
The use of methamphetamine can result in fatal kidney and lung disorders, brain damage, liver damage, blood clots, chronic depression, hallucinations, violent and aggressive behavior, malnutrition, disturbed personality development, deficient immune system and psychosis. Children born to mothers who are abusers of methamphetamine can be born addicted and suffer birth defects, low birth weight, tremors, excessive crying, attention deficit disorder and behavior disorders.
 
In addition to the physical consequences to an individual who uses methamphetamine, usage of the drug also produces an increase in automobile accidents, explosions and fires, increased criminal activity, increased medical costs due to emergency room visits, increases in domestic violence, increased spread of infectious diseases and a loss in worker productivity.
 
That environmental damage is another consequence of the methamphetamine epidemic. Each pound of methamphetamine produced leaves behind five to six pounds of toxic waste. Chemicals and byproducts that result from the manufacture of methamphetamine are often poured into plumbing systems, storm drains or directly onto the ground. Clean up of methamphetamine laboratories is extremely resource-intensive, with an average remediation cost of five thousand dollars.

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